5ZIT

Crystal structure of human Enterovirus D68 RdRp in complex with NADPH

5ZIT の概要

• エントリーDOI: 10.2210/pdb5zit/pdb
• 分子名称: RdRp, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• 機能のキーワード: evd68-rdrp, complex, inhibitor, nadph-na4, structure-based design, rna binding protein
• 由来する生物種: Enterovirus D68
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52764.80

構造登録者

Wang, M.L.,Li, L.,Chen, Y.P.,Jiang, H.,Zhang, Y.,Su, D. (登録日: 2018-03-17, 公開日: 2019-04-17, 最終更新日: 2023-11-22)

• 主引用文献: Li, L.,Wang, M.,Chen, Y.,Hu, T.,Yang, Y.,Zhang, Y.,Bi, G.,Wang, W.,Liu, E.,Han, J.,Lu, T.,Su, D.; Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.; J.Struct.Biol., :107510-107510, 2020; PubMed: 32353513; DOI: 10.1016/j.jsb.2020.107510

実験手法

X-RAY DIFFRACTION (3.196 Å)