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5ZHL

Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor

Summary for 5ZHL
Entry DOI10.2210/pdb5zhl/pdb
DescriptortRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide (3 entities in total)
Functional Keywordstrna methyltransferase, transferase
Biological sourceMycobacterium tuberculosis CDC 1551
Total number of polymer chains1
Total formula weight26597.06
Authors
Zhong, W.,Pasunooti, K.K.,Balamkundu, S.,Wong, Y.W.,Nah, Q.,Liu, C.F.,Lescar, J.,Dedon, P.C. (deposition date: 2018-03-13, release date: 2019-03-06, Last modification date: 2023-11-22)
Primary citationZhong, W.,Pasunooti, K.K.,Balamkundu, S.,Wong, Y.H.,Nah, Q.,Gadi, V.,Gnanakalai, S.,Chionh, Y.H.,McBee, M.E.,Gopal, P.,Lim, S.H.,Olivier, N.,Buurman, E.T.,Dick, T.,Liu, C.F.,Lescar, J.,Dedon, P.C.
Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62:7788-7805, 2019
Cited by
PubMed: 31442049
DOI: 10.1021/acs.jmedchem.9b00582
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

217705

数据于2024-03-27公开中

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