5ZHJ

Crystal structure of TrmD from Mycobacterium tuberculosis in complex with S-adenosyl homocysteine (SAH)

5ZHJ の概要

• エントリーDOI: 10.2210/pdb5zhj/pdb
• 分子名称: tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: trna methyltransferase, transferase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26646.99

構造登録者

Zhong, W.,Pasunooti, K.K.,Balamkundu, S.,Wong, Y.W.,Nah, Q.,Liu, C.F.,Lescar, J.,Dedon, P.C. (登録日: 2018-03-13, 公開日: 2019-03-06, 最終更新日: 2023-11-22)

• 主引用文献: Zhong, W.,Pasunooti, K.K.,Balamkundu, S.,Wong, Y.H.,Nah, Q.,Gadi, V.,Gnanakalai, S.,Chionh, Y.H.,McBee, M.E.,Gopal, P.,Lim, S.H.,Olivier, N.,Buurman, E.T.,Dick, T.,Liu, C.F.,Lescar, J.,Dedon, P.C.; Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.; J.Med.Chem., 62:7788-7805, 2019; PubMed: 31442049; DOI: 10.1021/acs.jmedchem.9b00582

実験手法

X-RAY DIFFRACTION (1.75 Å)