5ZHE
STRUCTURE OF E. COLI UNDECAPRENYL DIPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-981
Summary for 5ZHE
| Entry DOI | 10.2210/pdb5zhe/pdb |
| Descriptor | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), 2-hydroxy-6-(tetradecyloxy)benzoic acid (3 entities in total) |
| Functional Keywords | metal-binding, substrate binding, acidocalcisomal pyrophosphatase, transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Escherichia coli K-12 |
| Total number of polymer chains | 2 |
| Total formula weight | 57312.75 |
| Authors | Gao, J.,Liu, W.D.,Zheng, Y.Y.,Ko, T.P.,Chen, C.C.,Guo, R.T. (deposition date: 2018-03-13, release date: 2019-03-13, Last modification date: 2023-11-22) |
| Primary citation | Malwal, S.R.,Chen, L.,Hicks, H.,Qu, F.,Liu, W.,Shillo, A.,Law, W.X.,Zhang, J.,Chandnani, N.,Han, X.,Zheng, Y.,Chen, C.C.,Guo, R.T.,AbdelKhalek, A.,Seleem, M.N.,Oldfield, E. Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis. J.Med.Chem., 62:2564-2581, 2019 Cited by PubMed: 30730737DOI: 10.1021/acs.jmedchem.8b01878 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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