5ZH4

CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-7

5ZH4 の概要

• エントリーDOI: 10.2210/pdb5zh4/pdb
• 分子名称: Lysine-tRNA ligase, LYSINE, (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ... (4 entities in total)
• 機能のキーワード: krs, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Plasmodium falciparum NF54 (Plasmodium falciparum (isolate NF54))
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 118470.18

構造登録者

Babbar, P.,Malhotra, N.,Sharma, M.,Harlos, K.,Reddy, D.S.,Manickam, Y.,Sharma, A. (登録日: 2018-03-11, 公開日: 2018-06-27, 最終更新日: 2023-11-22)

• 主引用文献: Das, P.,Babbar, P.,Malhotra, N.,Sharma, M.,Jachak, G.R.,Gonnade, R.G.,Shanmugam, D.,Harlos, K.,Yogavel, M.,Sharma, A.,Reddy, D.S.; Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite; J. Med. Chem., 61:5664-5678, 2018; PubMed: 29779382; DOI: 10.1021/acs.jmedchem.8b00565

実験手法

X-RAY DIFFRACTION (2.6 Å)