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5ZF4

Structure of human dihydroorotate dehydrogenase in complex with 275-10-COOMe

Summary for 5ZF4
Entry DOI10.2210/pdb5zf4/pdb
DescriptorDihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywordsrossmann fold, dihydroorotate/orotate, ubiquinone/ubiquinol, mitochondrial inner membrane, inhibitor complex, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight44295.16
Authors
Miyazaki, Y.,Inaoka, K.D.,Shiba, T.,Saimoto, H.,Amalia, E.,Kido, Y.,Sakai, C.,Nakamura, M.,Moore, L.A.,Harada, S.,Kita, K. (deposition date: 2018-03-02, release date: 2018-09-26, Last modification date: 2023-11-22)
Primary citationMiyazaki, Y.,Inaoka, D.K.,Shiba, T.,Saimoto, H.,Sakura, T.,Amalia, E.,Kido, Y.,Sakai, C.,Nakamura, M.,Moore, A.L.,Harada, S.,Kita, K.
Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9:997-997, 2018
Cited by
PubMed: 30233375
DOI: 10.3389/fphar.2018.00997
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.66 Å)
Structure validation

217705

數據於2024-03-27公開中

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