5ZF4

Structure of human dihydroorotate dehydrogenase in complex with 275-10-COOMe

5ZF4 の概要

• エントリーDOI: 10.2210/pdb5zf4/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
• 機能のキーワード: rossmann fold, dihydroorotate/orotate, ubiquinone/ubiquinol, mitochondrial inner membrane, inhibitor complex, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44295.16

構造登録者

Miyazaki, Y.,Inaoka, K.D.,Shiba, T.,Saimoto, H.,Amalia, E.,Kido, Y.,Sakai, C.,Nakamura, M.,Moore, L.A.,Harada, S.,Kita, K. (登録日: 2018-03-02, 公開日: 2018-09-26, 最終更新日: 2023-11-22)

• 主引用文献: Miyazaki, Y.,Inaoka, D.K.,Shiba, T.,Saimoto, H.,Sakura, T.,Amalia, E.,Kido, Y.,Sakai, C.,Nakamura, M.,Moore, A.L.,Harada, S.,Kita, K.; Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.; Front Pharmacol, 9:997-997, 2018; PubMed: 30233375; DOI: 10.3389/fphar.2018.00997

実験手法

X-RAY DIFFRACTION (1.66 Å)