5ZBT

Structure of legume lectin-like domain from Entamoeba histolytica

5ZBT の概要

• エントリーDOI: 10.2210/pdb5zbt/pdb
• 分子名称: Lectin-like protein (2 entities in total)
• 機能のキーワード: ergic-like, unknown function
• 由来する生物種: Entamoeba histolytica HM-1:IMSS-A
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28356.57

構造登録者

Khan, F.,Suguna, K. (登録日: 2018-02-12, 公開日: 2019-02-20, 最終更新日: 2024-11-20)

主引用文献

Khan, F.,Suguna, K.
Crystal structure of the legume lectin-like domain of an ERGIC-53-like protein from Entamoeba histolytica
Acta Crystallogr F Struct Biol Commun, 75:197-204, 2019

PubMed Abstract: ERGIC-53-like proteins are type I membrane proteins that belong to the class of intracellular cargo receptors and are known to be indispensable for the intracellular transport of glycoproteins. They are implicated in transporting glycoproteins between the endoplasmic reticulum and the Golgi body. The crystal structure of the legume lectin-like domain of an ERGIC-53-like protein from Entamoeba histolytica has been determined at 2.4 Å resolution. Although the overall structure of the domain resembles those of its mammalian and yeast orthologs (ERGIC-53 and Emp46, respectively), there are significant changes in the carbohydrate-binding site. A sequence-based search revealed the presence of several homologs of ERGIC-53 in different species of Entamoeba. This is the first report of the structural characterization of a member of this class of proteins from a protozoan and serves to further knowledge and understanding regarding the species-specific differences.

PubMed: 30839295
DOI: 10.1107/S2053230X19000499

実験手法

X-RAY DIFFRACTION (2.4 Å)