5ZAD
Human topoisomerase II beta in complex with DNA
Summary for 5ZAD
Entry DOI | 10.2210/pdb5zad/pdb |
Related | 3QX3 |
Descriptor | DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (4 entities in total) |
Functional Keywords | dna binding and cleavage, isomerase-dna complex, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 196038.73 |
Authors | Sun, L.Y.,Zhu, L.W.,Tang, Y.J. (deposition date: 2018-02-07, release date: 2019-03-20, Last modification date: 2023-11-22) |
Primary citation | Sun, L.Y.,Zhu, L.W.,Tang, Y.J. Increasing the distance between two monomers of topoisomerase II beta under the action of antitumor agent 4 beta-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin. Sci Rep, 8:14949-14949, 2018 Cited by PubMed: 30297860DOI: 10.1038/s41598-018-33366-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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