5ZAD

Human topoisomerase II beta in complex with DNA

Summary for 5ZAD

• Entry DOI: 10.2210/pdb5zad/pdb
• Related: 3QX3
• Descriptor: DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (4 entities in total)
• Functional Keywords: dna binding and cleavage, isomerase-dna complex, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 196038.73

Authors

Sun, L.Y.,Zhu, L.W.,Tang, Y.J. (deposition date: 2018-02-07, release date: 2019-03-20, Last modification date: 2023-11-22)

• Primary citation: Sun, L.Y.,Zhu, L.W.,Tang, Y.J.; Increasing the distance between two monomers of topoisomerase II beta under the action of antitumor agent 4 beta-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin.; Sci Rep, 8:14949-14949, 2018; PubMed: 30297860; DOI: 10.1038/s41598-018-33366-2

Experimental method

X-RAY DIFFRACTION (2.54 Å)