5Z55

NMR Solution Structure of the Kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

5Z55 の概要

• エントリーDOI: 10.2210/pdb5z55/pdb
• 分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1 (1 entity in total)
• 機能のキーワード: ror1, kringle, oncoprotein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane ; Single-pass type I membrane protein: Q01973
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9562.52

構造登録者

Ma, X.,Hu, K.F. (登録日: 2018-01-17, 公開日: 2018-05-16, 最終更新日: 2024-10-23)

主引用文献

Ma, X.,Zhang, Y.,Liu, B.,Yang, J.,Hu, K.
Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).
Biomol NMR Assign, 12:145-148, 2018

PubMed Abstract: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expresses at high level in many cancers and has been suggested as a potential therapeutic target. It was reported that the Kringle (KNG) domain of ROR1 extracellular region is involved in ROR1/ROR2 heterooligomerization. Monoantibodies that target KNG domain of ROR1 could induce apoptosis of chronic lymphocytic leukemia cells. Here we present the backbone and side chain assignments of KNG domain of ROR1, which lays a foundation for its further structural and function research.

PubMed: 29313214
DOI: 10.1007/s12104-017-9797-9

実験手法

SOLUTION NMR