5Z2Q

Vgll1-TEAD4 core complex

「4EAZ」から置き換えられました

5Z2Q の概要

• エントリーDOI: 10.2210/pdb5z2q/pdb
• 分子名称: Transcription cofactor vestigial-like protein 1, Transcriptional enhancer factor TEF-3, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: tead, transcription factor, co-regulator, vgll1, vestigial, transcription
• 由来する生物種: Mus musculus (Mouse); 詳細
• 細胞内の位置: Nucleus : Q99NC0 Q99NC0 Q62296 Q62296
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 64660.74

構造登録者

Pobbati, A.V.,Song, H. (登録日: 2018-01-03, 公開日: 2018-01-31, 最終更新日: 2023-11-22)

主引用文献

Pobbati, A.V.,Chan, S.W.,Lee, I.,Song, H.,Hong, W.
Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.
Structure, 20:1135-1140, 2012

PubMed Abstract: The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is determined in this study. Remarkably, Vgll1 interacts with TEAD in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5, a proliferation-promoting gene, and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ, Vgll1 has the potential to promote cancer progression.

PubMed: 22632831
DOI: 10.1016/j.str.2012.04.004

実験手法

X-RAY DIFFRACTION (2.74 Å)