5Z1R
Crystal Structure Analysis of the BRD4
Summary for 5Z1R
Entry DOI | 10.2210/pdb5z1r/pdb |
Descriptor | Bromodomain-containing protein 4, 5-bromo-N-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-2-methoxybenzene-1-sulfonamide, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | brd4(1), bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17548.93 |
Authors | |
Primary citation | Xiang, Q.,Zhang, Y.,Li, J.,Xue, X.,Wang, C.,Song, M.,Zhang, C.,Wang, R.,Li, C.,Wu, C.,Zhou, Y.,Yang, X.,Li, G.,Ding, K.,Xu, Y. Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer. Acs Med.Chem.Lett., 9:262-267, 2018 Cited by PubMed: 29541371DOI: 10.1021/acsmedchemlett.8b00003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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