5Z1D

MAP2K7 C276S mutant-inhibitor

5Z1D の概要

• エントリーDOI: 10.2210/pdb5z1d/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 7, N-[3-(6-methyl-1H-indazol-3-yl)phenyl]prop-2-enamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37498.47

構造登録者

Kinoshita, T.,London, N. (登録日: 2017-12-26, 公開日: 2019-01-02, 最終更新日: 2023-11-22)

• 主引用文献: Shraga, A.,Olshvang, E.,Davidzohn, N.,Khoshkenar, P.,Germain, N.,Shurrush, K.,Carvalho, S.,Avram, L.,Albeck, S.,Unger, T.,Lefker, B.,Subramanyam, C.,Hudkins, R.L.,Mitchell, A.,Shulman, Z.,Kinoshita, T.,London, N.; Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.; Cell Chem Biol, 26:98-108.e5, 2019; PubMed: 30449673; DOI: 10.1016/j.chembiol.2018.10.011

実験手法

X-RAY DIFFRACTION (2.28 Å)