5YY3

Crystal structure of AsqI

5YY3 の概要

• エントリーDOI: 10.2210/pdb5yy3/pdb
• 分子名称: Uncharacterized protein AsqI (2 entities in total)
• 機能のキーワード: hemocyanin like protein, aspoquinolone biosynthesis, secondary metabolism, metal binding protein
• 由来する生物種: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 85640.62

構造登録者

Hara, K.,Hashimoto, H.,Kishimoto, S.,Watanabe, K. (登録日: 2017-12-07, 公開日: 2018-08-01, 最終更新日: 2024-03-27)

主引用文献

Kishimoto, S.,Hara, K.,Hashimoto, H.,Hirayama, Y.,Champagne, P.A.,Houk, K.N.,Tang, Y.,Watanabe, K.
Enzymatic one-step ring contraction for quinolone biosynthesis.
Nat Commun, 9:2826-2826, 2018

PubMed Abstract: The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities. Here we report in vitro and computational analyses leading to the discovery of a hemocyanin-like protein AsqI from the Aspergillus nidulans aspoquinolone biosynthetic pathway that forms viridicatins via a conversion of the cyclopenin-type 6,7-bicyclic system into the viridicatin-type 6,6-bicyclic core through elimination of carbon dioxide and methylamine through methyl isocyanate.

PubMed: 30026518
DOI: 10.1038/s41467-018-05221-5

実験手法

X-RAY DIFFRACTION (2.305 Å)