5YY1

Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI739

Summary for 5YY1

• Entry DOI: 10.2210/pdb5yy1/pdb
• Descriptor: GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: kras, g12c, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 1
• Total formula weight: 20411.29

Authors

Swaminathan, S.,Thakur, M.K.,Kandan, S.,Gautam, A.,Kanavalli, M.,Simhadri, P.,Gosu, R. (deposition date: 2017-12-07, release date: 2018-04-18, Last modification date: 2023-11-22)

• Primary citation: Swaminathan, S.,Thakur, M.K.,Kandan, S.,Gautam, A.,Kanavalli, M.,Simhadri, P.,Gosu, R.; Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI739; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.69 Å)