5YU9

Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib

Summary for 5YU9

• Entry DOI: 10.2210/pdb5yu9/pdb
• Related: 4YNJ
• Descriptor: Epidermal growth factor receptor, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: egfr, t790m, ibrutinib, inhibitor, oncoprotein
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 4
• Total formula weight: 152470.74

Authors

Yan, X.E.,Yun, C.H. (deposition date: 2017-11-21, release date: 2017-12-27, Last modification date: 2023-11-22)

• Primary citation: Wang, A.,Yan, X.E.,Wu, H.,Wang, W.,Hu, C.,Chen, C.,Zhao, Z.,Zhao, P.,Li, X.,Wang, L.,Wang, B.,Ye, Z.,Wang, J.,Wang, C.,Zhang, W.,Gray, N.S.,Weisberg, E.L.,Chen, L.,Liu, J.,Yun, C.H.,Liu, Q.; Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation.; Oncotarget, 7:69760-69769, 2016; PubMed: 27626175; DOI: 10.18632/oncotarget.11951

Experimental method

X-RAY DIFFRACTION (1.95 Å)