5YQO

Crystal structure of Sirt2 in complex with selective inhibitor L5C

5YQO の概要

• エントリーDOI: 10.2210/pdb5yqo/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, N-[4-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: nad-dependent deacetylase sirtuin-2, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35017.67

構造登録者

Wang, H.,Yu, Y.,Li, G.,Chen, Q. (登録日: 2017-11-07, 公開日: 2018-10-17, 最終更新日: 2023-11-22)

• 主引用文献: Yang, L.L.,Wang, H.L.,Zhong, L.,Yuan, C.,Liu, S.Y.,Yu, Z.J.,Liu, S.,Yan, Y.H.,Wu, C.,Wang, Y.,Wang, Z.,Yu, Y.,Chen, Q.,Li, G.B.; X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.; Eur J Med Chem, 155:806-823, 2018; PubMed: 29957526; DOI: 10.1016/j.ejmech.2018.06.041

実験手法

X-RAY DIFFRACTION (1.483 Å)