5YOJ

Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657

5YOJ の概要

• エントリーDOI: 10.2210/pdb5yoj/pdb
• 分子名称: A17 HIV-1 protease, (4R)-N-[(2,6-dimethylphenyl)methyl]-3-[(2S,3S)-3-[[(2S)-2-[(7-methoxy-1-benzofuran-2-yl)carbonylamino]-2-[(3R)-oxolan-3 -yl]ethanoyl]amino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22690.71

構造登録者

Adachi, M.,Hidaka, K.,Kuroki, R.,Kiso, Y. (登録日: 2017-10-29, 公開日: 2018-07-11, 最終更新日: 2024-03-27)

• 主引用文献: Hidaka, K.,Kimura, T.,Sankaranarayanan, R.,Wang, J.,McDaniel, K.F.,Kempf, D.J.,Kameoka, M.,Adachi, M.,Kuroki, R.,Nguyen, J.T.,Hayashi, Y.,Kiso, Y.; Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.; J. Med. Chem., 61:5138-5153, 2018; PubMed: 29852069; DOI: 10.1021/acs.jmedchem.7b01709

実験手法

X-RAY DIFFRACTION (1.5 Å)