5YLO

Structural of Pseudomonas aeruginosa PA4980

5YLO の概要

• エントリーDOI: 10.2210/pdb5ylo/pdb
• 分子名称: Probable enoyl-CoA hydratase/isomerase, GLYCEROL (3 entities in total)
• 機能のキーワード: enoyl-coa hydratase activity, fatty acid beta-oxidation, hydrolase
• 由来する生物種: Pseudomonas aeruginosa PAO1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29045.86

構造登録者

Liu, L.,Li, T.,Peng, C.T.,Li, C.C.,Xiao, Q.J.,He, L.H.,Wang, N.Y.,Bao, R. (登録日: 2017-10-18, 公開日: 2018-08-22, 最終更新日: 2024-03-27)

主引用文献

Liu, L.,Li, T.,Peng, C.T.,Sun, C.Z.,Li, C.C.,Xiao, Q.J.,He, L.H.,Wang, N.Y.,Song, Y.J.,Zhu, Y.B.,Li, H.,Kang, M.,Tang, H.,Xiong, X.,Bao, R.
Structural characterization of a Delta3, Delta2-enoyl-CoA isomerase from Pseudomonas aeruginosa: implications for its involvement in unsaturated fatty acid metabolism.
J.Biomol.Struct.Dyn., 37:2695-2702, 2019

PubMed Abstract: Gene PA4980 from Pseudomonas aeruginosa encodes a putative enoyl-coenzyme A hydratase/isomerase that is associated with the function of the biofilm dispersion-inducing signal molecule cis-2-decenoic acid. To elucidate the role of PA4980 in cis-2-decenoic acid biosynthesis, we reported the crystal structure of its protein product at 2.39 Å. The structural analysis and substrate binding prediction suggest that it acts as a monofunctional enoyl-coenzyme A isomerase, implicating an alternative pathway of the cis-2-decenoic acid synthesis.

PubMed: 30052139
DOI: 10.1080/07391102.2018.1495102

実験手法

X-RAY DIFFRACTION (2.39 Å)