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5YLJ

Crystal structure of T2R-TTL-Millepachine complex

Summary for 5YLJ
Entry DOI10.2210/pdb5ylj/pdb
DescriptorTubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one, ... (13 entities in total)
Functional Keywordscolchicine binding domain, tubulin inhibitor, tublin, millepachine, structural protein
Biological sourceSus scrofa (Pig)
More
Total number of polymer chains6
Total formula weight265314.79
Authors
Yang, J.H.,Chen, L.J. (deposition date: 2017-10-17, release date: 2018-04-11, Last modification date: 2024-03-27)
Primary citationYang, J.H.,Yan, W.,Yu, Y.M.,Wang, Y.X.,Yang, T.,Xue, L.L.,Yuan, X.,Long, C.F.,Liu, Z.W.,Chen, X.X.,Hu, M.S.,Zheng, L.,Qiu, Q.,Pei, H.Y.,Li, D.,Wang, F.,Bai, P.,Wen, J.L.,Ye, H.Y.,Chen, L.J.
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 293:9461-9472, 2018
Cited by
PubMed: 29691282
DOI: 10.1074/jbc.RA117.001658
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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