5YJK
Human kallikrein 7 in complex with 1,4-diazepane-7-one 1-acetamide derivative
Summary for 5YJK
Entry DOI | 10.2210/pdb5yjk/pdb |
Related | 5Y9L |
Descriptor | Kallikrein-7, (R)-2-(6-(5-chloro-2-methoxybenzyl)-3-(2,2-dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl)-N-(3-(methylsulfonyl)phenyl)acetamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | protease, inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : P49862 |
Total number of polymer chains | 1 |
Total formula weight | 25088.11 |
Authors | |
Primary citation | Murafuji, H.,Sakai, H.,Goto, M.,Imajo, S.,Sugawara, H.,Muto, T. Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors Bioorg. Med. Chem. Lett., 27:5272-5276, 2017 Cited by PubMed: 29102227DOI: 10.1016/j.bmcl.2017.10.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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