5YI5

human ferritin mutant - E-helix deletion

5YI5 の概要

• エントリーDOI: 10.2210/pdb5yi5/pdb
• EMDBエントリー: 6714 6830
• 分子名称: Ferritin heavy chain (1 entity in total)
• 機能のキーワード: ferritin, cage, drug delivery, transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 494594.52

構造登録者

Lee, S.G.,Yoon, H.R.,Ahn, B.J.,Jeong, H.,Hyun, J.,Jung, Y.,Kim, H. (登録日: 2017-10-02, 公開日: 2018-02-21, 最終更新日: 2024-03-27)

主引用文献

Ahn, B.,Lee, S.G.,Yoon, H.R.,Lee, J.M.,Oh, H.J.,Kim, H.M.,Jung, Y.
Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release
Angew. Chem. Int. Ed. Engl., 57:2909-2913, 2018

PubMed Abstract: Human ferritins are emerging platforms for non-toxic protein-based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug loading. However, reliable strategies for high-level drug encapsulation within ferritin cavities and prompt cellular drug release are still lacking. Ferritin nanocages were developed with partially opened hydrophobic channels, which provide stable routes for spontaneous and highly accumulated loading of Fe -conjugated drugs as well as pH-responsive rapid drug release at endoplasmic pH. Multiple cancer-related compounds, such as doxorubicin, curcumin, and quercetin, were actively and heavily loaded onto the prepared nicked ferritin. Drugs on these minimally modified ferritins were effectively delivered inside cancer cells with high toxicity.

PubMed: 29359486
DOI: 10.1002/anie.201800516

実験手法

ELECTRON MICROSCOPY (3 Å)