5YFZ

Plasmodium vivax SHMT bound with PLP-glycine and S-GS626

5YFZ の概要

• エントリーDOI: 10.2210/pdb5yfz/pdb
• 分子名称: Serine hydroxymethyltransferase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], 2-[1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-fluoranyl-phenyl]piperidin-4-yl]ethanoic acid, ... (5 entities in total)
• 機能のキーワード: alpha and beta protein, transferase, methyltransferase activity, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 150097.54

構造登録者

Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U.,Schwertz, G.,Diederich, F. (登録日: 2017-09-22, 公開日: 2018-06-06, 最終更新日: 2023-11-22)

• 主引用文献: Schwertz, G.,Witschel, M.C.,Rottmann, M.,Leartsakulpanich, U.,Chitnumsub, P.,Jaruwat, A.,Amornwatcharapong, W.,Ittarat, W.,Schafer, A.,Aponte, R.A.,Trapp, N.,Chaiyen, P.,Diederich, F.; Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold; ChemMedChem, 13:931-943, 2018; PubMed: 29655285; DOI: 10.1002/cmdc.201800053

実験手法

X-RAY DIFFRACTION (2.16 Å)