5YEA

The crystal structure of Lp-PLA2 in complex with a novel inhibitor

5YEA の概要

• エントリーDOI: 10.2210/pdb5yea/pdb
• 分子名称: Platelet-activating factor acetylhydrolase, SULFATE ION, 4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3-cyano-phenyl]sulfamoyl]benzoic acid, ... (4 entities in total)
• 機能のキーワード: hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89093.51

構造登録者

Liu, Q.F.,Xu, Y.C. (登録日: 2017-09-15, 公開日: 2018-07-25, 最終更新日: 2023-11-22)

• 主引用文献: Liu, Q.,Huang, F.,Yuan, X.,Wang, K.,Zou, Y.,Shen, J.,Xu, Y.; Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2.; J. Med. Chem., 60:10231-10244, 2017; PubMed: 29193967; DOI: 10.1021/acs.jmedchem.7b01530

実験手法

X-RAY DIFFRACTION (1.805 Å)