5YCZ

Crystal structure of Alocasin, protease inhibitor from Giant Taro (Arum macrorrhizon)

Summary for 5YCZ

Entry DOI	10.2210/pdb5ycz/pdb
Descriptor	Trypsin/chymotrypsin inhibitor (2 entities in total)
Functional Keywords	protease inhibitor, storage protein, tubers, alocasia, alocasin, kunitz type, plant protein
Biological source	Alocasia macrorrhizos (Giant taro)
Total number of polymer chains	2
Total formula weight	39586.28
Authors	Vajravijayan, S.,Pletnev, S.,Nandhagopal, N.,Gunasekaran, K. (deposition date: 2017-09-08, release date: 2018-06-13, Last modification date: 2024-10-23)
Primary citation	Vajravijayan, S.,Pletnev, S.,Pletnev, V.Z.,Nandhagopal, N.,Gunasekaran, K. Crystal structure of a novel Kunitz type inhibitor, alocasin with anti-Aedes aegypti activity targeting midgut proteases. Pest Manag. Sci., 74:2761-2772, 2018 Cited by PubMed Abstract: The pesticidal properties of many Kunitz-type inhibitors have been reported previously; however, the mechanism of action is not well established. In this study, the activity of alocasin against Aedes aegypti is demonstrated and the structure-activity relationship of this Kunitz-type inhibitor is explained through X-ray structure analyses. PubMed: 29737039 DOI: 10.1002/ps.5063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.502 Å)

Structure validation