5YCZ

Crystal structure of Alocasin, protease inhibitor from Giant Taro (Arum macrorrhizon)

5YCZ の概要

• エントリーDOI: 10.2210/pdb5ycz/pdb
• 分子名称: Trypsin/chymotrypsin inhibitor (2 entities in total)
• 機能のキーワード: protease inhibitor, storage protein, tubers, alocasia, alocasin, kunitz type, plant protein
• 由来する生物種: Alocasia macrorrhizos (Giant taro)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39586.28

構造登録者

Vajravijayan, S.,Pletnev, S.,Nandhagopal, N.,Gunasekaran, K. (登録日: 2017-09-08, 公開日: 2018-06-13, 最終更新日: 2024-10-23)

主引用文献

Vajravijayan, S.,Pletnev, S.,Pletnev, V.Z.,Nandhagopal, N.,Gunasekaran, K.
Crystal structure of a novel Kunitz type inhibitor, alocasin with anti-Aedes aegypti activity targeting midgut proteases.
Pest Manag. Sci., 74:2761-2772, 2018

PubMed Abstract: The pesticidal properties of many Kunitz-type inhibitors have been reported previously; however, the mechanism of action is not well established. In this study, the activity of alocasin against Aedes aegypti is demonstrated and the structure-activity relationship of this Kunitz-type inhibitor is explained through X-ray structure analyses.

PubMed: 29737039
DOI: 10.1002/ps.5063

実験手法

X-RAY DIFFRACTION (2.502 Å)