5YB1

Structure and function of human serum albumin-metal agent complex

Summary for 5YB1

• Entry DOI: 10.2210/pdb5yb1/pdb
• Descriptor: Serum albumin, PALMITIC ACID, ~{N},~{N},12-trimethyl-3$l^{3}-thia-1$l^{4},5,6$l^{4}-triaza-2$l^{3}-cupratricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,6,9,11-pentaen-4-amine, ... (4 entities in total)
• Functional Keywords: albumin, metal complex, pro-drug, drug carrier, target therapy, lipid binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 136591.34

Authors

Yang, F.,Wang, T.,Wang, J.,Gou, Y.,Zhang, Z.L. (deposition date: 2017-09-02, release date: 2018-09-05, Last modification date: 2023-11-22)

• Primary citation: Wang, J.,Gou, Y.,Zhang, Z.,Yu, P.,Qi, J.,Qin, Q.,Sun, H.,Wu, X.,Liang, H.,Yang, F.; Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin.; Mol. Pharm., 15:2180-2193, 2018; PubMed: 29722993; DOI: 10.1021/acs.molpharmaceut.8b00045

Experimental method

X-RAY DIFFRACTION (2.616 Å)