5Y9L

Human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one

5Y9L の概要

• エントリーDOI: 10.2210/pdb5y9l/pdb
• 分子名称: Kallikrein-7, 3-[2-[(3Z,6R)-6-[(5-chloranyl-2-methoxy-phenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxidanylidene-1,4-diazepan-1-yl]ethanoylamino]benzoic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protease, inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : P49862
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25018.58

構造登録者

Sugawara, H. (登録日: 2017-08-25, 公開日: 2017-11-29, 最終更新日: 2023-11-22)

• 主引用文献: Murafuji, H.,Sakai, H.,Goto, M.,Imajo, S.,Sugawara, H.,Muto, T.; Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors; Bioorg. Med. Chem. Lett., 27:5272-5276, 2017; PubMed: 29102227; DOI: 10.1016/j.bmcl.2017.10.030

実験手法

X-RAY DIFFRACTION (2.15 Å)