5Y0G

Crystal structure of human FABP4 complexed with ligand 4-Fluoro-3-((4-methoxynaphthalene)-1-sulfonamido) benzoic acid

5Y0G の概要

• エントリーDOI: 10.2210/pdb5y0g/pdb
• 分子名称: Fatty acid-binding protein, adipocyte, 4-fluoranyl-3-[(4-methoxynaphthalen-1-yl)sulfonylamino]benzoic acid (3 entities in total)
• 機能のキーワード: lipid binding protein, fabp4, inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17286.64

構造登録者

Su, H.X.,Liu, Q.F.,Xu, Y.C. (登録日: 2017-07-17, 公開日: 2018-06-06, 最終更新日: 2023-11-22)

• 主引用文献: Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X.; From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4; Eur J Med Chem, 154:44-59, 2018; PubMed: 29775936; DOI: 10.1016/j.ejmech.2018.05.007

実験手法

X-RAY DIFFRACTION (1.542 Å)