5XZF

Vitamin D receptor with a synthetic ligand ADRO1

5XZF の概要

• エントリーDOI: 10.2210/pdb5xzf/pdb
• 分子名称: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6S)-6-(1-adamantyl)-6-oxidanyl-hex-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (5 entities in total)
• 機能のキーワード: vitamin d receptor, vitamin d analogue, adamantan, transcription
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32730.73

構造登録者

Otero, R.,Numoto, N.,Ikura, T.,Yamada, S.,Mourino, A.,Makishima, M.,Ito, N. (登録日: 2017-07-12, 公開日: 2018-07-25, 最終更新日: 2023-11-22)

• 主引用文献: Otero, R.,Ishizawa, M.,Numoto, N.,Ikura, T.,Ito, N.,Tokiwa, H.,Mourino, A.,Makishima, M.,Yamada, S.; 25 S-Adamantyl-23-yne-26,27-dinor-1 alpha ,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.; J. Med. Chem., 61:6658-6673, 2018; PubMed: 29989817; DOI: 10.1021/acs.jmedchem.8b00427

実験手法

X-RAY DIFFRACTION (2.1 Å)