5XYX
The structure of p38 alpha in complex with a triazol inhibitor
Summary for 5XYX
Entry DOI | 10.2210/pdb5xyx/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-(2-chloro-6-fluorobenzyl)-5-(furan-2-yl)-2H-1,2,4-triazol-3-amine (2 entities in total) |
Functional Keywords | p38 map kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 43807.24 |
Authors | |
Primary citation | Wang, Y.,Sun, Y.,Cao, R.,Liu, D.,Xie, Y.,Li, L.,Qi, X.,Huang, N. In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem., 60:8552-8564, 2017 Cited by PubMed: 28945083DOI: 10.1021/acs.jmedchem.7b01075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report