5XWV

Substrate-bound Structure of a Ketoreductase from the Second Module of the amphotericin Polyketide Synthases

5XWV の概要

• エントリーDOI: 10.2210/pdb5xwv/pdb
• 分子名称: AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, S-[2-[3-[[(2R)-3,3-dimethyl-2,4-bis(oxidanyl)butanoyl]amino]propanoylamino]ethyl] (2R)-2-methyl-3-oxidanylidene-pentanethioate, ... (4 entities in total)
• 機能のキーワード: modular polyketide synthease, ketoreductase, oxidoreductase
• 由来する生物種: Streptomyces nodosus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105121.23

構造登録者

Liu, C.,Zheng, J. (登録日: 2017-06-30, 公開日: 2018-06-06, 最終更新日: 2023-11-22)

• 主引用文献: Liu, C.,Yuan, M.,Xu, X.,Wang, L.,Keatinge-Clay, A.T.,Deng, Z.,Lin, S.,Zheng, J.; Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.; J. Struct. Biol., 203:135-141, 2018; PubMed: 29626512; DOI: 10.1016/j.jsb.2018.04.001

実験手法

X-RAY DIFFRACTION (1.8 Å)