5XVA

Crystal Structure of PAK4 in complex with inhibitor CZH216

Summary for 5XVA

Entry DOI	10.2210/pdb5xva/pdb
Descriptor	Serine/threonine-protein kinase PAK 4, [6-chloranyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone, ETHANOL, ... (4 entities in total)
Functional Keywords	atp binding pocket, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : O96013
Total number of polymer chains	1
Total formula weight	33668.57
Authors	Zhao, F.,Li, H. (deposition date: 2017-06-27, release date: 2018-02-07, Last modification date: 2023-11-22)
Primary citation	Hao, C.,Zhao, F.,Song, H.,Guo, J.,Li, X.,Jiang, X.,Huan, R.,Song, S.,Zhang, Q.,Wang, R.,Wang, K.,Pang, Y.,Liu, T.,Lu, T.,Huang, W.,Wang, J.,Lin, B.,He, Z.,Li, H.,Li, F.,Zhao, D.,Cheng, M. Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem., 61:265-285, 2018 Cited by PubMed: 29190083 DOI: 10.1021/acs.jmedchem.7b01342 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.847 Å)

Structure validation