5XUO

Pks13 AT domain fragment from Mycobacterium tuberculosis

5XUO の概要

• エントリーDOI: 10.2210/pdb5xuo/pdb
• 分子名称: Polyketide synthase Pks13 (2 entities in total)
• 機能のキーワード: fragment, transferase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11949.54

構造登録者

Yu, M.J.,Gu, Y.J.,Dou, C.,Cheng, W. (登録日: 2017-06-24, 公開日: 2018-05-02, 最終更新日: 2024-03-27)

主引用文献

Yu, M.,Dou, C.,Gu, Y.,Cheng, W.
Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain fromMycobacterium tuberculosis
PeerJ, 6:e4728-e4728, 2018

PubMed Abstract: Type I polyketide synthase 13 (Pks13) is involved in the final step of the biosynthesis of mycolic acid in . Recent articles have reported that Pks13 is an essential enzyme in the mycolic acid biosynthesis pathway, and it has been deeply studied as a drug target in Tuberculosis. We report a high-resolution structure of the acyltransferase (AT) domain of Pks13 at 2.59 Å resolution. Structural comparison with the full-length AT domain (PDB code, 3TZW, and 3TZZ) reveals a different orientation of the C-terminal helix and rearrangement of some conserved residues.

PubMed: 29761048
DOI: 10.7717/peerj.4728

実験手法

X-RAY DIFFRACTION (2.586 Å)