5XT5

SufS-SufU complex from Bacillus subtilis

Summary for 5XT5

• Entry DOI: 10.2210/pdb5xt5/pdb
• Descriptor: Zinc-dependent sulfurtransferase SufU, Cysteine desulfurase SufS, ZINC ION, ... (5 entities in total)
• Functional Keywords: iron-sulfur cluster biosynthesis, suf machinery, cysteine desulfurase, sulfur mobilization, metalloprotein, biosynthetic protein
• Biological source: Bacillus subtilis (strain 168); More
• Total number of polymer chains: 4
• Total formula weight: 128311.53

Authors

Fujishiro, T.,Takahashi, Y. (deposition date: 2017-06-17, release date: 2017-12-20, Last modification date: 2023-11-22)

Primary citation

Fujishiro, T.,Terahata, T.,Kunichika, K.,Yokoyama, N.,Maruyama, C.,Asai, K.,Takahashi, Y.
Zinc-Ligand Swapping Mediated Complex Formation and Sulfur Transfer between SufS and SufU for Iron-Sulfur Cluster Biogenesis in Bacillus subtilis
J. Am. Chem. Soc., 139:18464-18467, 2017

PubMed Abstract: SufU is a zinc-containing protein involved in mobilization of sulfur from SufS for iron-sulfur cluster biogenesis of Bacillus subtilis. Structural basis for the sulfur transfer in SufS-SufU complex was revealed. A zinc-ligand exchange reaction upon SufS-SufU complexation provides a free thiol from Cys41 of SufU as a sulfur acceptor.

PubMed: 29235855
DOI: 10.1021/jacs.7b11307

Experimental method

X-RAY DIFFRACTION (2.34 Å)