5XSR
novel orally efficacious inhibitors complexed with PARP1
Summary for 5XSR
Entry DOI | 10.2210/pdb5xsr/pdb |
Descriptor | Poly [ADP-ribose] polymerase 1, 6-fluoranyl-2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | complex structure, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P09874 |
Total number of polymer chains | 1 |
Total formula weight | 40088.74 |
Authors | |
Primary citation | Chen, X.,Huan, X.,Liu, Q.,Wang, Y.,He, Q.,Tan, C.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.,Yang, C. Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Eur J Med Chem, 145:389-403, 2018 Cited by PubMed: 29335205DOI: 10.1016/j.ejmech.2018.01.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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