5XMV
Plasmodium vivax SHMT bound with PLP-glycine and GS362
5XMV の概要
エントリーDOI | 10.2210/pdb5xmv/pdb |
分子名称 | Serine hydroxymethyltransferase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], (4~{S})-6-azanyl-4-[3-(2-chlorophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5- carbonitrile, ... (5 entities in total) |
機能のキーワード | alpha and beta protein, transferase, methyltransferase activity, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Plasmodium vivax |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 150155.68 |
構造登録者 | Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U.,Schwertz, G.,Diederich, F. (登録日: 2017-05-16, 公開日: 2017-11-29, 最終更新日: 2023-11-22) |
主引用文献 | Schwertz, G.,Frei, M.S.,Witschel, M.C.,Rottmann, M.,Leartsakulpanich, U.,Chitnumsub, P.,Jaruwat, A.,Ittarat, W.,Schafer, A.,Aponte, R.A.,Trapp, N.,Mark, K.,Chaiyen, P.,Diederich, F. Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs Chemistry, 23:14345-14357, 2017 Cited by PubMed: 28967982DOI: 10.1002/chem.201703244 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.16 Å) |
構造検証レポート
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