5XJ4

Complex structure of durvalumab-scFv/PD-L1

Summary for 5XJ4

• Entry DOI: 10.2210/pdb5xj4/pdb
• Related: 5XJ3
• Descriptor: Programmed cell death 1 ligand 1, durvalumab-VH, durvalumab-VL, ... (4 entities in total)
• Functional Keywords: durvalumab, pd-l1, complex structure, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7
• Total number of polymer chains: 3
• Total formula weight: 51092.38

Authors

Tan, S.,Liu, K.,Chai, Y.,Gao, G.F.,Qi, J. (deposition date: 2017-04-29, release date: 2018-04-25, Last modification date: 2023-11-22)

• Primary citation: Tan, S.,Liu, K.,Chai, Y.,Zhang, C.W.,Gao, S.,Gao, G.F.,Qi, J.; Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab; Protein Cell, 9:135-139, 2018; PubMed: 28488247; DOI: 10.1007/s13238-017-0412-8

Experimental method

X-RAY DIFFRACTION (2.3 Å)