5XI1

Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)

Summary for 5XI1

• Entry DOI: 10.2210/pdb5xi1/pdb
• Descriptor: RNA (5'-R(P*CP*CP*GP*CP*AP*GP*CP*GP*G)-3'), 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE (2 entities in total)
• Functional Keywords: myricetin, flavonoids, cag rna, hd, huntington's disease, trinucleotide repeats, rna
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 6408.07

Authors

Tawani, A.,Mishra, S.K.,Khan, E.,Kumar, A. (deposition date: 2017-04-25, release date: 2018-08-08, Last modification date: 2023-06-14)

• Primary citation: Khan, E.,Tawani, A.,Mishra, S.K.,Verma, A.K.,Upadhyay, A.,Kumar, M.,Sandhir, R.,Mishra, A.,Kumar, A.; Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs).; ACS Chem. Biol., 13:180-188, 2018; PubMed: 29172480; DOI: 10.1021/acschembio.7b00699

Experimental method

SOLUTION NMR