5XI1

Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)

5XI1 の概要

• エントリーDOI: 10.2210/pdb5xi1/pdb
• 分子名称: RNA (5'-R(P*CP*CP*GP*CP*AP*GP*CP*GP*G)-3'), 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE (2 entities in total)
• 機能のキーワード: myricetin, flavonoids, cag rna, hd, huntington's disease, trinucleotide repeats, rna
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 6408.07

構造登録者

Tawani, A.,Mishra, S.K.,Khan, E.,Kumar, A. (登録日: 2017-04-25, 公開日: 2018-08-08, 最終更新日: 2024-05-15)

• 主引用文献: Khan, E.,Tawani, A.,Mishra, S.K.,Verma, A.K.,Upadhyay, A.,Kumar, M.,Sandhir, R.,Mishra, A.,Kumar, A.; Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs).; ACS Chem. Biol., 13:180-188, 2018; PubMed: 29172480; DOI: 10.1021/acschembio.7b00699

実験手法

SOLUTION NMR