5XF6

Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having an ethylenediamine linker

5XF6 の概要

• エントリーDOI: 10.2210/pdb5xf6/pdb
• 関連するPDBエントリー: 5XF3 5XF4 5XF5
• 分子名称: Histone H3.2, ETHANE-1,2-DIAMINE, Histone H4, ... (11 entities in total)
• 機能のキーワード: nucleosome, histone adduct, ruthenium compound, binuclear metal-based agent, structural protein-dna complex, structural protein/dna
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• 細胞内の位置: Nucleus: P84233 P62799 P02281
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 199494.41

構造登録者

Ma, Z.,Adhireksan, Z.,Murray, B.S.,Dyson, P.J.,Davey, C.A. (登録日: 2017-04-07, 公開日: 2017-10-11, 最終更新日: 2023-11-22)

• 主引用文献: Davey, G.E.,Adhireksan, Z.,Ma, Z.,Riedel, T.,Sharma, D.,Padavattan, S.,Rhodes, D.,Ludwig, A.,Sandin, S.,Murray, B.S.,Dyson, P.J.,Davey, C.A.; Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation; Nat Commun, 8:1575-1575, 2017; PubMed: 29146919; DOI: 10.1038/s41467-017-01680-4

実験手法

X-RAY DIFFRACTION (2.63 Å)