5XDA
Structural basis for Ufm1 recognition by UfSP
Summary for 5XDA
| Entry DOI | 10.2210/pdb5xda/pdb |
| Descriptor | Ufm1-specific protease, Ubiquitin-fold modifier 1 (3 entities in total) |
| Functional Keywords | complex, molecular recognition, hydrolase |
| Biological source | Caenorhabditis elegans More |
| Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein : Q94218 |
| Total number of polymer chains | 12 |
| Total formula weight | 438309.21 |
| Authors | |
| Primary citation | Kim, K.H.,Ha, B.H.,Kim, E.E. Structural basis for Ufm1 recognition by UfSP FEBS Lett., 592:263-273, 2018 Cited by PubMed Abstract: Ubiquitin and ubiquitin-like proteins (Ubls) are involved in a variety of cellular functions, and dysfunction of these proteins often leads to disease, thus requiring the precise molecular recognition of the partner. Here, we report a structural basis for the recognition of Ufm1 by the Ufm1-specific protease (UfSP), both from Caenorhabditis elegans. Ufm1 functions in endoplasmic reticulum homeostasis, cell cycle regulation, and dysfunctions of this protein can result in breast cancer and neurological disorders. The structure reveals that in addition to the extended β-structure at the C-terminus of cUfm1, the interactions made by the completely conserved residues in Ufm1 orthologs, Pro88-Val92, corresponding to P6-P2 positions from the cleavage site, seem to be important for the specific recognition of Ufm1 by cUfSP. PubMed: 29251776DOI: 10.1002/1873-3468.12951 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.285 Å) |
Structure validation
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