5XDA

Structural basis for Ufm1 recognition by UfSP

5XDA の概要

• エントリーDOI: 10.2210/pdb5xda/pdb
• 分子名称: Ufm1-specific protease, Ubiquitin-fold modifier 1 (3 entities in total)
• 機能のキーワード: complex, molecular recognition, hydrolase
• 由来する生物種: Caenorhabditis elegans; 詳細
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein : Q94218
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 438309.21

構造登録者

Kim, K.H.,Ha, B.H.,Kim, E.E. (登録日: 2017-03-28, 公開日: 2018-02-28, 最終更新日: 2024-10-30)

主引用文献

Kim, K.H.,Ha, B.H.,Kim, E.E.
Structural basis for Ufm1 recognition by UfSP
FEBS Lett., 592:263-273, 2018

PubMed Abstract: Ubiquitin and ubiquitin-like proteins (Ubls) are involved in a variety of cellular functions, and dysfunction of these proteins often leads to disease, thus requiring the precise molecular recognition of the partner. Here, we report a structural basis for the recognition of Ufm1 by the Ufm1-specific protease (UfSP), both from Caenorhabditis elegans. Ufm1 functions in endoplasmic reticulum homeostasis, cell cycle regulation, and dysfunctions of this protein can result in breast cancer and neurological disorders. The structure reveals that in addition to the extended β-structure at the C-terminus of cUfm1, the interactions made by the completely conserved residues in Ufm1 orthologs, Pro88-Val92, corresponding to P6-P2 positions from the cleavage site, seem to be important for the specific recognition of Ufm1 by cUfSP.

PubMed: 29251776
DOI: 10.1002/1873-3468.12951

実験手法

X-RAY DIFFRACTION (3.285 Å)