5WXD

Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1)

5WXD の概要

• エントリーDOI: 10.2210/pdb5wxd/pdb
• 関連するPDBエントリー: 5WXC
• 分子名称: HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, H7-25 (3 entities in total)
• 機能のキーワード: hla-a*2402, h1n1, h5n1, h1-25, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44831.95

構造登録者

Zhao, M.,Liu, K.,Chai, Y.,Qi, J.,Liu, J.,Gao, G.F. (登録日: 2017-01-07, 公開日: 2018-01-17, 最終更新日: 2024-10-23)

主引用文献

Zhao, M.,Liu, K.,Luo, J.,Tan, S.,Quan, C.,Zhang, S.,Chai, Y.,Qi, J.,Li, Y.,Bi, Y.,Xiao, H.,Wong, G.,Zhou, J.,Jiang, T.,Liu, W.,Yu, H.,Yan, J.,Liu, Y.,Shu, Y.,Wu, G.,Wu, A.,Gao, G.F.,Liu, W.J.
Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.
Mbio, 9:-, 2018

PubMed Abstract: Against a backdrop of seasonal influenza virus epidemics, emerging avian influenza viruses (AIVs) occasionally jump from birds to humans, posing a public health risk, especially with the recent sharp increase in H7N9 infections. Evaluations of cross-reactive T-cell immunity to seasonal influenza viruses and human-infecting AIVs have been reported previously. However, the roles of influenza A virus-derived epitopes in the cross-reactive T-cell responses and heterosubtypic protections are not well understood; understanding those roles is important for preventing and controlling new emerging AIVs. Here, among the members of a healthy population presumed to have previously been infected by pandemic H1N1 (pH1N1), we found that pH1N1-specific T cells showed cross- but biased reactivity to human-infecting AIVs, i.e., H5N1, H6N1, H7N9, and H9N2, which correlates with distinct protections. Through a T-cell epitope-based phylogenetic analysis, the cellular immunogenic clustering expanded the relevant conclusions to a broader range of virus strains. We defined the potential key conserved epitopes required for cross-protection and revealed the molecular basis for the immunogenic variations. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development. We revealed preexisting but biased T-cell reactivity of pH1N1 influenza virus to human-infecting AIVs, which provided distinct protections. The cross-reactive T-cell recognition had a regular pattern that depended on the T-cell epitope matrix revealed via bioinformatics analysis. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.

PubMed: 30087171
DOI: 10.1128/mBio.01408-18

実験手法

X-RAY DIFFRACTION (3.295 Å)