Crystal structure of the KH1 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C complex with RNA

Summary for 5WWW

Related5WWX 5WWZ
DescriptorRNA-binding E3 ubiquitin-protein ligase MEX3C, RNA (5'-R(*GP*UP*UP*UP*AP*G)-3') (3 entities in total)
Functional Keywordskh1, mex-3c, rna, rna binding protein-rna complex, rna binding protein/rna
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  Q5U5Q3
Total number of polymer chains2
Total molecular weight12405.35
Yang, L.,Wang, C.,Li, F.,Gong, Q. (deposition date: 2017-01-05, release date: 2017-08-23, Last modification date: 2017-10-11)
Primary citation
Yang, L.,Wang, C.,Li, F.,Zhang, J.,Nayab, A.,Wu, J.,Shi, Y.,Gong, Q.
The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
J. Biol. Chem., 292:16221-16234, 2017
PubMed: 28808060 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M117.797746
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.2092003.0%0.41MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution