5WUU
Complex structure of the first bromodomain of BRD4 with an inhibitor that containing a 2H-chromen-2-one ring
Summary for 5WUU
Entry DOI | 10.2210/pdb5wuu/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide (3 entities in total) |
Functional Keywords | brd4, inhibitor, complex, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 17037.59 |
Authors | |
Primary citation | Sun, Z.,Zhang, H.,Chen, Z.,Xie, Y.,Jiang, H.,Chen, L.,Ding, H.,Zhang, Y.,Jiang, H.,Zheng, M.,Luo, C. Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays. Bioorg. Med. Chem. Lett., 27:2003-2009, 2017 Cited by PubMed: 28347667DOI: 10.1016/j.bmcl.2017.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.724 Å) |
Structure validation
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