5WUU

Complex structure of the first bromodomain of BRD4 with an inhibitor that containing a 2H-chromen-2-one ring

5WUU の概要

• エントリーDOI: 10.2210/pdb5wuu/pdb
• 分子名称: Bromodomain-containing protein 4, ~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide (3 entities in total)
• 機能のキーワード: brd4, inhibitor, complex, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17037.59

構造登録者

Zhang, H.,Sun, Z.Y. (登録日: 2016-12-21, 公開日: 2017-04-12, 最終更新日: 2023-11-22)

• 主引用文献: Sun, Z.,Zhang, H.,Chen, Z.,Xie, Y.,Jiang, H.,Chen, L.,Ding, H.,Zhang, Y.,Jiang, H.,Zheng, M.,Luo, C.; Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.; Bioorg. Med. Chem. Lett., 27:2003-2009, 2017; PubMed: 28347667; DOI: 10.1016/j.bmcl.2017.03.012

実験手法

X-RAY DIFFRACTION (1.724 Å)