5WT7

FAS1-IV domain of Human Periostin

Summary for 5WT7

• Entry DOI: 10.2210/pdb5wt7/pdb
• Descriptor: Periostin (1 entity in total)
• Functional Keywords: periostin, integrin, cell adhesion, cancer, chronic allergic inflammation disease
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15711.11

Authors

Yun, H.,Lee, C.W. (deposition date: 2016-12-09, release date: 2017-12-13, Last modification date: 2024-05-15)

Primary citation

Yun, H.,Kim, E.H.,Lee, C.W.
1H,13C, and 15N resonance assignments of FAS1-IV domain of human periostin, a component of extracellular matrix proteins.
Biomol NMR Assign, 12:95-98, 2018

PubMed Abstract: Periostin, an extracellular matrix protein, is secreted by fibroblasts and is overexpressed in various types of cancers. The four internal repeat fasciclin 1 (FAS1) domains of human periostin play crucial roles in promoting tumor metastasis and progression via interaction with cell surface integrins. Among four FAS1 domains of human periostin, the fourth FAS1 domain (FAS1-IV) was prepared for NMR study, since only FAS1-IV was highly soluble, and showed a well-dispersed 2D H-N HSQC spectrum. Here, we report nearly complete backbone and side chain resonance assignments and a secondary structural analysis of the FAS1-IV domain as first steps toward the structure determination of FAS1-IV of human periostin.

PubMed: 29086898
DOI: 10.1007/s12104-017-9786-z

Experimental method

SOLUTION NMR