5WT7

FAS1-IV domain of Human Periostin

5WT7 の概要

• エントリーDOI: 10.2210/pdb5wt7/pdb
• 分子名称: Periostin (1 entity in total)
• 機能のキーワード: periostin, integrin, cell adhesion, cancer, chronic allergic inflammation disease
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15711.11

構造登録者

Yun, H.,Lee, C.W. (登録日: 2016-12-09, 公開日: 2017-12-13, 最終更新日: 2024-05-15)

主引用文献

Yun, H.,Kim, E.H.,Lee, C.W.
1H,13C, and 15N resonance assignments of FAS1-IV domain of human periostin, a component of extracellular matrix proteins.
Biomol NMR Assign, 12:95-98, 2018

PubMed Abstract: Periostin, an extracellular matrix protein, is secreted by fibroblasts and is overexpressed in various types of cancers. The four internal repeat fasciclin 1 (FAS1) domains of human periostin play crucial roles in promoting tumor metastasis and progression via interaction with cell surface integrins. Among four FAS1 domains of human periostin, the fourth FAS1 domain (FAS1-IV) was prepared for NMR study, since only FAS1-IV was highly soluble, and showed a well-dispersed 2D H-N HSQC spectrum. Here, we report nearly complete backbone and side chain resonance assignments and a secondary structural analysis of the FAS1-IV domain as first steps toward the structure determination of FAS1-IV of human periostin.

PubMed: 29086898
DOI: 10.1007/s12104-017-9786-z

実験手法

SOLUTION NMR