5WR7

Crystal structure of Trk-A complexed with a selective inhibitor CH7057288

Summary for 5WR7

• Entry DOI: 10.2210/pdb5wr7/pdb
• Descriptor: High affinity nerve growth factor receptor, N-tert-butyl-2-[2-[6,6-dimethyl-8-(methylsulfonylamino)-11-oxidanylidene-naphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methyl-pyridine-4-carboxamide (3 entities in total)
• Functional Keywords: trk-a, kinase domain, high affinity nerve growth factor receptor, proteros biostructures gmbh, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35315.63

Authors

Tanaka, H.,Blaesse, M.,Augustin, M.,Goesser, C. (deposition date: 2016-11-30, release date: 2017-12-06, Last modification date: 2018-12-19)

• Primary citation: Tanaka, H.,Sase, H.,Tsukaguchi, T.,Hasegawa, M.,Tanimura, H.,Yoshida, M.,Sakata, K.,Fujii, T.,Tachibana, Y.,Takanashi, K.,Higashida, A.,Hasegawa, K.,Ono, Y.,Oikawa, N.,Mio, T.; Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer.; Mol. Cancer Ther., 17:2519-2529, 2018; PubMed: 30242093; DOI: 10.1158/1535-7163.MCT-17-1180

Experimental method

X-RAY DIFFRACTION (2.76 Å)